Quantification of Dynamic 11C-Phenytoin PET Studies

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies

Objective(s): Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using 11C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical 11C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to...

A Quantification Framework of Brain Receptor Dynamic PET Studies

Z. Jane Wang, Zsolt Szabo, Peng Lei, Jozsef Varga, and K. J. Ray Liu Department of Electrical and Computer Engineering, University of British Columbia, Canada 2 Department of Radiology, Johns Hopkins University Medical Institutions, MD 3 Department of Nuclear Medicine, University of Debrecen, Hungary 4 Department of Electrical and Computer Engineering and Institute for Systems Research Universi...

Dynamic PET/CT with 11C-acetate in prostate cancer.

Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

PURPOSE Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [11C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TSPO that can serve as reference. The high variability in binding observed using this method has motivated the use of simplified ratio-based approaches such as standardised uptake...

Quantification and accuracy of clinical [11C]-PiB PET/MRI: the effect of MR-based attenuation correction

The Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Denmark The Dixon-Water-Fat segmentation (DWFS) method is a standard attenuation correction (AC) method in PET/MRI on the Siemens mMR and has demonstrated a systematic quantitative bias in [18F]-FDG-PET/MRI studies of the brain compared to PET/CT. The aim of this study was to evaluate the impact of DWFS-AC in a hyb...